Secukinumab

(Cosentyx®)

Cosentyx®

Drug updated on 3/28/2024

Dosage FormInjection (subcutaneous; 150 mg/mL); Pediatric injection; (subcutaneous; 75 mg/0.5 mL); Powder for injection (subcutaneous; 150 mg)
Drug ClassHuman interleukin-17A antagonists
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • For the treatment of moderate to severe plaque psoriasis in patients 6 years and older who are candidates for systemic therapy or phototherapy.
  • For the treatment of active psoriatic arthritis (PsA) in patients 2 years of age and older.
  • For the treatment of adults with active ankylosing spondylitis (AS).
  • For the treatment of adults with active non-radiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation .
  • For the treatment of active enthesitis-related arthritis (ERA) in patients 4 years of age and older.

Summary
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  • Secukinumab (Cosentyx) is indicated for the treatment of moderate to severe plaque psoriasis in patients 6 years and older, active psoriatic arthritis (PsA) in patients 2 years and older, adults with active ankylosing spondylitis (AS), adults with non-radiographic axial spondyloarthritis (nr-axSpA), and enthesitis-related arthritis (ERA) in patients aged 4 or above.
  • A total of 62 systematic reviews/meta-analyses were reviewed to evaluate the safety and effectiveness of secukinumab compared to other biologics.
  • In treating moderate-to-severe plaque psoriasis, secukinumab demonstrated a high response ratio indicating superiority over etanercept and comparable efficacy against ixekizumab.
  • For AS and nr-axSpA conditions, secukinumab showed similar efficacy as TNF inhibitors while some evidence suggested superior long-term outcomes than other IL-17 inhibitors.
  • When used for PsA treatment, alongside other IL-17/IL23 inhibitors it significantly improved outcomes related to arthritis symptoms including enthesis issues along with skin manifestations.
  • The safety profile across all indications was generally favorable; no new safety signals were identified during long-term studies on this drug's use.
  • Serious infection risks associated with Cosentyx are comparable to those seen when using other biologic drugs; low rates of tuberculosis reactivation have been observed among users too which indicates its relative safety profile regarding infections risk management.
  • Elderly individuals suffering from psoriasis responded well both effectively & safely towards this medication suggesting that age alone should not deter its usage despite increased prevalence rate concerning comorbidities within such population groupings.
  • Subgroup analyses reflected broad applicability especially amongst TNFi-naïve or experienced patient groups where it exhibited significant efficacy.
  • Secukinumab was found to be effective in treating challenging manifestations of PsA such as enthesitis and dactylitis, with rapid and sustained resolution observed.

Product Monograph / Prescribing Information

Document TitleYearSource
Cosentyx (secukinumab) Prescribing Information.2021Novartis Pharmaceuticals Corporation, East Hanover, NJ

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.2023Annals of the Rheumatic Diseases
Efficacy and safety of secukinumab for the treatment of psoriasis: A meta-analysis of pivotal phase III trials2023Dermatology
Clinical and Economic Benefit of Advanced Therapies for the Treatment of Active Ankylosing Spondylitis2023Rheumatology and therapy
Optimization of secukinumab dose regimens in patients with moderate-to-severe plaque psoriasis via exposure-response modeling2023Expert review of clinical pharmacology
Targeted therapies for patients with moderate-to-severe psoriasis: a systematic review and network meta-analysis of PASI response at 1 year. 2022Journal of Dermatological Treatment
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta‐analysis. 2022Cochrane Database of Systematic Reviews
Assessment report: Cosentyx.2022EMA
Efficacy of bimekizumab and other biologics in moderate to severe plaque psoriasis: a systematic literature review and a network meta-analysis.2022Dermatology and Therapy
Bullous pemphigoid induced by biologic drugs in psoriasis: a systematic review.2022Journal of Dermatological Treatment
Biologics for pediatric moderate-to-severe plaque psoriasis: a systematic review and network meta-analysis.2022Journal of the German Society of Dermatology
Biologic disease-modifying antirheumatic drugs for preventing radiographic progression in psoriatic arthritis: a systematic review and network meta-analysis.2022Pharmaceutics
Targeted systemic therapies for psoriatic arthritis: a systematic review and comparative synthesis of short-term articular. dermatological, enthesitis and dactylitis outcomes.2022Rheumatic & Muscoskeletal Diseases
Biologics for pediatric psoriasis: A systematic review and meta-analysis2022Pediatric dermatology
Efficacy of Bimekizumab and Other Biologics in Moderate to Severe Plaque Psoriasis: A Systematic Literature Review and a Network Meta-Analysis2022Dermatology and therapy
Towards Personalized Medicine in Psoriasis: Current Progress2022Psoriasis
Comparative Efficacy and Safety of Janus Kinase Inhibitors and Secukinumab in Patients with Active Ankylosing Spondylitis: A Systematic Review and Meta-Analysis2022Pharmacology
Understanding efficacy-safety balance of biologics in moderate-to-severe pediatric psoriasis2022Frontiers in medicine
Number Needed to Treat Network Meta-Analysis to Compare Biologic Drugs for Moderate-to-Severe Psoriasis2022Advances in therapy
Comparative Efficacy of Biologic Disease-Modifying Anti-Rheumatic Drugs for Non-Radiographic Axial Spondyloarthritis: A Systematic Literature Review and Bucher Indirect Comparisons2022Inflammopharmacology
Evidence for the Use of Secukinumab in Patients with Radiographic and Non-radiographic Axial Spondyloarthritis in the Last 5 Years2022Rheumatology and therapy
Comparative efficacy of secukinumab against adalimumab and infliximab in patients with moderate-to-severe plaque psoriasis2022Chinese medical journal
Efficacy and Safety of Secukinumab in Elderly Subjects with Moderate to Severe Plaque Psoriasis: A Pooled Analysis of Phase III Studies2022Seminars in arthritis and rheumatism
Impact of biologics on health-related quality of life in patients with Ankylosing spondylitis: A systematic review and meta-analysis of randomized controlled trials2022Seminars in arthritis and rheumatism
Secukinumab for treating non-radiographic axial spondyloarthritis. 2021NICE
Dose adjustment of biologic treatments for moderate-to-severe plaque psoriasis in the real world: a systematic review. 2021Dermatology and Therapy
Efficacy and safety of interleukin-17A inhibitors in patients with ankylosing spondylitis: a systematic review and meta-analysis of randomized controlled trials. 2021Clinical Rheumatology
Efficacy and safety of anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a meta-analysis. 2021Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Differences in biologics for treating ankylosing spondylitis: the contribution of network meta-analysis. 2021European Review for Medical and Pharmacological Sciences
Efficacy and safety of interleukin-17 inhibitors in the treatment of chronic rheumatic diseases: a combined and updated meta-analysis. 2021Journal of Clinical Pharmacy and Therapeutics
Comparative efficacy and relative ranking of biologics and oral therapies for moderate-to-severe plaque psoriasis: a network meta-analysis. 2021Dermatologic Therapy
Relative efficacy and safety of secukinumab and guselkumab for the treatment of active psoriatic arthritis: a network meta-analysis.2021International Journal of Clinical Pharmacology and Therapeutics
Comparative efficacy and safety of secukinumab, ixekizumab, and tofacitinib in patients with active psoriatic arthritis showing insufficient response to tumor necrosis factor inhibitors. 2021International Journal of Clinical Pharmacology and Therapeutics
A systematic review with network meta-analysis of the available biologic therapies for psoriatic disease domains. 2021Frontiers in Medicine
Secukinumab for treating moderate to severe plaque psoriasis in children and young people. 2021NICE
Short-term efficacy of biologic therapies in moderate-to-severe plaque psoriasis: a systematic literature review and an enhanced multinomial network meta-analysis.2021Dermatology and Therapy
Impact of biological agents on imaging and biomarkers of cardiovascular disease in patients with psoriasis: a systematic review and meta-analysis of randomized placebo-controlled trials.2021Journal of Investigative Dermatology
Achievement of Remission Endpoints with Secukinumab Over 3 Years in Active Ankylosing Spondylitis: Pooled Analysis of Two Phase 3 Studies2021Rheumatology and therapy
Comparative efficacy and safety of secukinumab and ixekizumab in patients with active ankylosing spondylitis2021Zeitschrift fur Rheumatologie
A Pooled Analysis Reporting the Efficacy and Safety of Secukinumab in Male and Female Patients with Ankylosing Spondylitis2021Rheumatology and therapy
Secukinumab Efficacy on Enthesitis in Patients With Ankylosing Spondylitis: Pooled Analysis of Four Pivotal Phase III Studies2021The Journal of rheumatology
Comparative efficacy and safety of secukinumab 75 mg, 150 mg, and 300 mg in patients with active ankylosing spondylitis2021International journal of clinical pharmacology and therapeutics
Short-term efficacy and safety of secukinumab for ankylosing spondylitis: a systematic review and meta-analysis of RCTs.2020Mediators of Inflammation
Drug survival of biologics in treating ankylosing spondylitis: a systematic review and meta-analysis of real-world evidence. 2020BioDrugs
Effectiveness and safety of systemic therapy for psoriasis in older adults: a systematic review. 2020JAMA Dermatology
The effects of selected biologics and a small molecule on health-related quality of life in adult plaque psoriasis patients: a systematic review and meta-analysis. 2020PLoS One
Comparing the efficacy and tolerability of biologic therapies in psoriasis: an updated network meta-analysis2020The British journal of dermatology
Pharmacological treatment of psoriatic arthritis: a systematic literature research for the 2019 update of the EULAR recommendations for the management of psoriatic arthritis2020Annals of the rheumatic diseases
Treatment of Dactylitis and Enthesitis in Psoriatic Arthritis with Biologic Agents: A Systematic Review and Metaanalysis2020The Journal of rheumatology
Fourteen small molecule and biological agents for psoriatic arthritis: A network meta-analysis of randomized controlled trials2020Medicine
Comparative effectiveness of targeted immunomodulators for the treatment of moderate-to-severe plaque psoriasis: A systematic review and network meta-analysis2020Arthritis research & therapy
Biological DMARD efficacy in psoriatic arthritis: a systematic literature review and meta-analysis on articular, enthesitis, dactylitis, skin and functional outcomes2020Clinical and experimental rheumatology
Rapid Response of Biologic Treatments of Moderate-to-Severe Plaque Psoriasis: A Comprehensive Investigation Using Bayesian and Frequentist Network Meta-analyses2020Dermatology and therapy
Short-term efficacy and safety of il-17, il-12/23, and il-23 inhibitors brodalumab, secukinumab, ixekizumab, ustekinumab, guselkumab, tildrakizumab, and risankizumab for the treatment of moderate to severe plaque psoriasis: a systematic review and network meta-analysis of randomized controlled trials.2019Journal of Immunology Research
Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis: integrated pooled clinical trial and post-marketing surveillance data2019Arthritis research & therapy
Secukinumab efficacy on resolution of enthesitis in psoriatic arthritis: pooled analysis of two phase 3 studies2019Arthritis research & therapy
Assessing the relative efficacy of interleukin-17 and interleukin-23 targeted treatments for moderate-to-severe plaque psoriasis: A systematic review and network meta-analysis of PASI response2019PloS one
A Cost-per-Number Needed to Treat Analysis Assessing the Efficiency of Biologic Drugs in Moderate to Severe Plaque Psoriasis2019Actas dermo-sifiliograficas
A systematic review and meta-analysis of the efficacy and safety of the interleukin (IL)-12/23 and IL-17 inhibitors ustekinumab, secukinumab, ixekizumab, brodalumab, guselkumab and tildrakizumab for the treatment of moderate to severe plaque psoriasis2018The Journal of dermatological treatment
A Systematic Review and Meta-analysis of Efficacy and Safety of Novel Interleukin Inhibitors in the Management of Psoriatic Arthritis2018Journal of clinical rheumatology
Secukinumab for psoriatic arthritis: comparative effectiveness versus licensed biologics/apremilast: a network meta-analysis2018Journal of comparative effectiveness research
Relative efficacy and safety of apremilast, secukinumab, and ustekinumab for the treatment of psoriatic arthritis2018Zeitschrift fur Rheumatologie
Comparative effectiveness of abatacept, apremilast, secukinumab and ustekinumab treatment of psoriatic arthritis: a systematic review and network meta-analysis2018Rheumatology international
Comparative effectiveness of secukinumab and adalimumab in ankylosing spondylitis as assessed by matching-adjusted indirect comparison2018European journal of rheumatology
Efficacy and Safety of Secukinumab in Elderly Subjects with Moderate to Severe Plaque Psoriasis: A Pooled Analysis of Phase III Studies2018Drugs & aging
Risk of serious infections in biological treatment of patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a meta-analysis2018Clinical rheumatology
Efficacy of Secukinumab in the Treatment of Moderate to Severe Plaque Psoriasis in the North American Subgroup of Patients: Pooled Analysis of Four Phase 3 Studies2018Dermatology and therapy
Number needed to treat and costs per responder among biologic treatments for moderate-to-severe psoriasis: a network meta-analysis2018Current medical research and opinion
Number needed to treat and costs per responder among biologic treatments for moderate-to-severe plaque psoriasis in Japan2018The Journal of dermatological treatment

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