Drug updated on 3/28/2024
Dosage Form | Injection (intramuscular: 0.5 mL) |
Drug Class | Vaccines |
Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- For active immunization against diphtheria, tetanus, and pertussis as a 5-dose series in infants and children aged 6 weeks through 6 years (prior to the seventh birthday).
Summary
- Diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed (Infanrix) is used for active immunization against diphtheria, tetanus, and pertussis in infants and children aged 6 weeks through 6 years.
- A systematic review/meta-analysis of ten studies was conducted to determine the effect of Tdap immunization during pregnancy on infants' responses to routine vaccinations.
- The study found that infants born to women who received Tdap vaccination during pregnancy had significantly lower levels of IgG antibodies against pertussis toxin, filamentous haemagglutinin (FHA), pertactin, and fimbria 2/3 after primary immunization compared with those born to unvaccinated women.
- These lower antibody levels persisted even after booster shots were given for FHA and FIM2/3 in the group whose mothers were vaccinated with Tdap during pregnancy.
- Infants from this same group also showed lower seroprotection rates against diphtheria following their primary vaccination but higher short-term as well as long-term seroprotection rates against Haemophilus influenzae type b when compared with counterparts from non-vaccinated mothers.
- Despite these findings suggesting a potential impact on infant immune response due to maternal Tdap vaccination during pregnancy, it's important that post-booster shot seroprotection rates remained high at 99% for both diphtheria and tetanus among all groups studied regardless of maternal status regarding receipt or non-receipt of the Tdap vaccine while pregnant.
Product Monograph / Prescribing Information
Document Title | Year | Source |
---|---|---|
Infanrix (diphtheria and tetanus toxoids and acellular pertussis vaccine) Prescribing Information. | 2023 | GlaxoSmithKline Durham, NC |
Systematic Reviews / Meta-Analyses
Document Title | Year | Source |
---|---|---|
The effect of tetanus-diphtheria-acellular-pertussis immunization during pregnancy on infant antibody responses: individual-participant data meta-analysis. | 2021 | Frontiers in Immunology |