Drugdocs | Pizensy®

Drug updated on 3/28/2024

Dosage Form	Solution (oral: 10 g/packet, 280 g/bottle, 560 g/bottle)
Drug Class	Osmotic laxatives
Ongoing and Completed Studies	ClinicalTrials.gov

Indication

Lactitol (Pizensy) is used in the treatment of chronic idiopathic constipation (CIC) in adults.
A systematic review and meta-analysis was conducted on one document that investigated the effectiveness and safety of laxatives, including lactitol, for constipation in elderly patients over 65 years old.
The study found that lactitol along with other medications such as psyllium, calcium polycarbophil, polyethylene glycol, magnesium hydroxide were more effective than placebo for short-term use within three months among elderly patients suffering from constipation.
In terms of safety profile across different types of laxatives studied - bulk laxative, osmotic laxative or stimulant laxative with or without fiber - there was no significant difference observed between them; frequency and severity of adverse effects were similar across all arms included in this analysis.
Among these drugs compared to Pizensy (lactitol), Polyethylene glycol seems to be safe and effective even for long-term use up to about six months specifically among elderly patients according to this reviewed document's findings.
However it should be noted that most studies included had a small sample size which may limit their generalizability; also overall quality assessment revealed they weren't high-quality trials hence further research might still be needed before making definitive conclusions regarding efficacy and safety profiles especially when considering long term usage beyond three months period.

Document Title	Year	Source
Pizensy (lactitol) Prescribing Information.	2020	Braintree Laboratories, Inc., Braintree, MA

Document Title	Year	Source
Medical management of constipation in elderly patients: systematic review.	2021	Journal of Neurogastroenterology