Drug updated on 4/18/2024
| Dosage Form | Gel (topical; 8.8%) |
| Drug Class | Proteolytic enzymes |
| Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for eschar removal in adults with deep partial thickness and/or full thickness thermal burns.
Summary
- Anacaulase (NexoBrid) is indicated for eschar removal in adults with deep partial thickness and/or full thickness thermal burns. It has been associated with positive effects on debridement outcomes, functional and cosmetic results, scarring, and quality of life improvements.
- The efficacy and safety profile of NexoBrid, including comparisons to other debridement methods, were analyzed in two systematic reviews/meta-analyses.
- When compared to other treatments for burn wound debridement, such as surgical excision or collagenase-based agents, NexoBrid has not been linked with significant adverse events like coagulopathy or burn wound infection, suggesting it is a safe option for patients requiring debridement.
- Key benefits of NexoBrid include quicker healing times due to the Bromelain-based approach. This reduces the need for surgical interventions, leading to shorter hospital stays and a lower risk of complications such as sepsis or compartment syndrome.
- Unlike collagenase, which is effective for burns covering less than 25% total body surface area (TBSA) and is usually used in outpatient settings, NexoBrid is beneficial even in treating deep burns that might require more intensive treatments.
- Although the benefits of NexoBrid are recognized, especially when used in conjunction with protocols that include analgosedation/locoregional anesthesia, further research with larger sample sizes and no conflicts of interest is necessary to fully understand bromelain’s effectiveness in treating various types of burns.
Product Monograph / Prescribing Information
| Document Title | Year | Source |
|---|---|---|
| NexoBrid (anacaulase-bcdb) Prescribing Information. | 2023 | Vericel Corporation, Cambridge, MA |
Systematic Reviews / Meta-Analyses
| Document Title | Year | Source |
|---|---|---|
| Bromelain-based enzymatic burn debridement: A systematic review of clinical studies on patient safety, efficacy and long-term outcomes. | 2023 | International wound journal |
| Clinical value of debriding enzymes as an adjunct to standard early surgical excision in human burns: A systematic review. | 2020 | Journal of burn case & research |