Drugdocs | Diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed

Drug updated on 3/28/2024

Dosage Form	Injection (intramuscular: 0.5 mL)
Drug Class	Vaccines
Ongoing and Completed Studies	ClinicalTrials.gov

Indication

For active immunization against diphtheria, tetanus, and pertussis as a 5-dose series in infants and children aged 6 weeks through 6 years (prior to the seventh birthday).

Diphtheria and tetanus toxoids and acellular pertussis vaccine adsorbed (Infanrix) is used for active immunization against diphtheria, tetanus, and pertussis in infants and children aged 6 weeks through 6 years.
A systematic review/meta-analysis of ten studies was conducted to determine the effect of Tdap immunization during pregnancy on infants' responses to routine vaccinations.
The study found that infants born to women who received Tdap vaccination during pregnancy had significantly lower levels of IgG antibodies against pertussis toxin, filamentous haemagglutinin (FHA), pertactin, and fimbria 2/3 after primary immunization compared with those born to unvaccinated women.
These lower antibody levels persisted even after booster shots were given for FHA and FIM2/3 in the group whose mothers were vaccinated with Tdap during pregnancy.
Infants from this same group also showed lower seroprotection rates against diphtheria following their primary vaccination but higher short-term as well as long-term seroprotection rates against Haemophilus influenzae type b when compared with counterparts from non-vaccinated mothers.
Despite these findings suggesting a potential impact on infant immune response due to maternal Tdap vaccination during pregnancy, it's important that post-booster shot seroprotection rates remained high at 99% for both diphtheria and tetanus among all groups studied regardless of maternal status regarding receipt or non-receipt of the Tdap vaccine while pregnant.

Document Title	Year	Source
Infanrix (diphtheria and tetanus toxoids and acellular pertussis vaccine) Prescribing Information.	2023	GlaxoSmithKline Durham, NC

Document Title	Year	Source
The effect of tetanus-diphtheria-acellular-pertussis immunization during pregnancy on infant antibody responses: individual-participant data meta-analysis.	2021	Frontiers in Immunology