Drug updated on 3/28/2024
| Dosage Form | Injection (intravenous: 5 g/50 mL, 10 g/100 mL) |
| Drug Class | Fatty acids |
| Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated as a source of calories and fatty acids in pediatric patients with parenteral nutrition-associated cholestasis (PANC).
Summary
- Fish oil triglycerides (Omegaven) are indicated as a source of calories and fatty acids in pediatric patients with parenteral nutrition-associated cholestasis (PANC).
- A network meta-analysis found that fish oil intravenous lipid emulsions, such as Omegaven, significantly reduced infection risk compared to other types of lipid emulsions. It also showed substantial reductions in hospital length of stay.
- Another randomized controlled trial revealed that supplementation with omega-3 fatty acids like those found in Omegaven led to a significant increase in serum levels of brain-derived neurotrophic factor (BDNF), which could have potential implications for neurological health.
- The benefits observed from the use of fish oil triglycerides were consistent across different patient populations and subgroups according to these studies. However, more research may be needed to confirm these findings across broader demographics.
- These conclusions come from three systematic reviews/meta-analyses on the effects and benefits associated with the use of fish oil triglycerides or similar compounds.
- One document was retracted due to inconsistencies discovered during an investigation following allegations raised by a third party; therefore its findings should not be considered reliable information about Omegaven's effectiveness or safety profile.
Product Monograph / Prescribing Information
| Document Title | Year | Source |
|---|---|---|
| Omegaven (fish oil triglycerides) Prescribing Information. | 2020 | Fresenius Kabi USA LLC, Grand Island, NY |
Systematic Reviews / Meta-Analyses
| Document Title | Year | Source |
|---|---|---|
| Omega-3 fatty acids in parenteral nutrition – a systematic review with network meta-analysis on clinical outcomes. | 2023 | Clinical Nutrition |
| A systematic review and meta-analysis of the omega-3 fatty acids effects on brain-derived neurotrophic factor (BDNF). | 2023 | Nutritional Neuroscience |
| Interventions to improve the nutritional status of under five children in Ethiopia: a systematic review. | 2023 | Public health Nutrition |
| Lipid emulsions for parenterally fed term and late preterm infants. | 2019 | Cochrane Database of Systematic Reviews |