Liraglutide

(Victoza®)

Liraglutide

Drug updated on 4/17/2024

Dosage FormInjection (subcutaneous; 6mg/mL (0.6 mg, 1.2 mg, 1.8 mg)
Drug ClassGlucagon-like peptide 1 (GLP-1) receptor agonists
Ongoing and
Completed Studies
ClinicalTrials.gov

Indication

  • Indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes mellitus.
  • Indicated to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus and established cardiovascular disease.

Summary
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  • Liraglutide (Victoza) is indicated as an adjunct to diet and exercise for improving glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes mellitus. It is also used to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus who have established cardiovascular disease.
  • A comprehensive understanding of liraglutide's safety profile, effectiveness, and comparisons with other treatments was provided through the analysis of 47 systematic reviews/meta-analyses, focusing on considerations for different population types and subgroups.
  • Compared to placebo and other treatments for Type 2 Diabetes Mellitus (T2DM), liraglutide showed significant improvements in cardiac function parameters such as left ventricular ejection fraction and stroke volume, suggesting its potential preventive measures against heart failure incidents.
  • The fixed-ratio combination of insulin degludec/liraglutide demonstrated better outcomes than placebo or GLP-1 receptor agonists (GLP1-RAs) alone without causing weight gain or severe hypoglycemic episodes, indicating a balanced safety-efficacy profile especially beneficial for managing T2DM.
  • Among Japanese patients with T2D, Tirzepatide was found to be more effective than liraglutide, highlighting the importance of personalized medicine approaches based on ethnic backgrounds.
  • For T2DM patients with Nonalcoholic Fatty Liver Disease (NAFLD), liraglutide achieved lower fasting plasma glucose levels compared to controls, positioning it as a potentially safer option over standard treatments currently available.
  • In terms of Cardiovascular Risk Management among T2DM patients, GLP-1 receptor agonists, including liraglutide, played vital roles by reducing cardiovascular events, showcasing their therapeutic benefits beyond just glycemic control alone.
  • Liraglutide, along with semaglutide, caused significant weight loss amongst obese/overweight non-diabetic adults, extending their utility beyond glucose metabolism to include weight management, which is a crucial factor in cardiovascular risk reduction.

Product Monograph / Prescribing Information

Document TitleYearSource
Victroza (liraglutide) prescribing information.2023Novo Nordisk A/S, DK-2880 Bagsvaerd, Denmark

Systematic Reviews / Meta-Analyses

Document TitleYearSource
Effect of liraglutide on cardiac function in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials.2024Medicine
Efficacy and safety of fixed-ratio combination insulin degludec/liraglutide in type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials.2024Diabetes/Metabolism Research and Reviews
Effect of tirzepatide on glycaemic control and weight loss compared with other glucagon-like peptide-1 receptor agonists in Japanese patients with type 2 diabetes mellitus.2024Diabetes, Obesity & Metabolism
Liraglutide on type 2 diabetes mellitus with nonalcoholic fatty liver disease: a systematic review and meta-analysis of 16 RCTs.2023Medicine
Effect of glucagon-like peptide-1 receptor agonists administration during coronary artery bypass grafting: a systematic review and meta-analysis of randomized control trials.2023Future Cardiology
Comparison of efficacy and safety of commercially available fixed-ratio combinations of insulin degludec/liraglutide and insulin glargine/lixisenatide: a network meta-analysis.2023Canadian Journal of Diabetes
The effects of cardioprotective antidiabetic therapy on microbiota in patients with type 2 diabetes mellitus-a systematic review.2023International Journal of Molecular Sciences
Liraglutide on type 2 diabetes mellitus with nonalcoholic fatty liver disease: a systematic review and meta-analysis of 16 RCTs.2023Medicine
The impact of glucagon-like peptide-1 receptor agonist on the cardiovascular outcomes in patients with type 2 diabetes mellitus: a meta-analysis and systematic review.2023Cardiology Research
Comparative effectiveness of multiple different treatment regimens for nonalcoholic fatty liver disease with type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis of randomised controlled trials.2023BMC Medicine
Effect of semaglutide and liraglutide in individuals with obesity or overweight without diabetes: a systematic review.2022Therapeutic Advances in Chronic Disease
Safety and efficacy of liraglutide on reducing visceral and ectopic fat in adults with or without type 2 diabetes mellitus: a systematic review and meta-analysis.2022Diabetes, Obesity, and Metabolism
Efficacy and safety of liraglutide and semaglutide on weight loss in people with obesity or overweight: a systematic review.2022Clinical Epidemiology
The effect of liraglutide on renal function in type 2 diabetes: a meta-analysis of randomized controlled studies.2022African Health Sciences
Efficacy of liraglutide in non-diabetic obese adults: a systematic review and meta-analysis of randomized controlled trials.2022Journal of Clinical Medicine
Medications for obesity management: effectiveness and value.2022ICER
Comparative efficacy and safety of glucose-lowering drugs in children and adolescents with type 2 diabetes: a systematic review and network meta-analysis.2022Frontiers in Endocrinology
The efficacy and safety of oral semaglutide for glycaemic management in adults with type 2 diabetes compared to subcutaneous semaglutide, placebo, and other GLP-1 RA comparators: a systematic review and network meta-analysis.2022Contemporary Clinical Trials Communicatons
Effects of glucagon-like peptide-1 receptor agonist (GLP-1RA) on cardiac structure and function: a systematic review and meta-analysis of randomized-controlled trials.2022Cardiovascular Drugs and Therapy
The effectiveness of SGLT2 inhibitor in the incidence of atrial fibrillation/atrial flutter in patients with type 2 diabetes mellitus/heart failure: a systematic review and meta-analysis.2022Journal of Thoracic Disease
Meta-analysis of seven heterogeneous studies on liraglutide add-on therapy in patients with type 2 diabetes mellitus treated with insulin.2022Diabetes & Metabolic Syndrome
Efficacy and safety of the new appetite suppressant, liraglutide: a meta-analysis of randomized controlled trials.2021Diabetes, Obesity and Metabolism
Efficacy and safety of liraglutide in type 2 diabetes mellitus patients complicated with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.2021Pharmacological Research
Effects of oral antidiabetic drugs and glucagon-like peptide-1 receptor agonists on left ventricular diastolic function in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis.2021Heart Failure Reviews
GLP-1 receptor agonists for cardiovascular outcomes with and without metformin. A systematic review and meta-analysis of cardiovascular outcomes trials.2021Diabetes Research and Clinical Practice
Comparative efficacy and safety of 8 GLP-1RAs in patients with type 2 diabetes: a network meta-analysis.2021Diabetes Research and Clinical Practice
Cardioprotective properties of glucagon-like peptide-1 receptor agonists in type 2 diabetes mellitus patients: a systematic review.2021Diabetes and Metabolic Syndrome
Liraglutide in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials.2021Clinics and Research in Hepatology and Gastroenterology
Comparison of the effects of 10 GLP-1 RA and SGLT2 inhibitor interventions on cardiovascular, mortality, and kidney outcomes in type 2 diabetes: a network meta-analysis of large randomized trials.2021Primary Care Diabetes
Effect of liraglutide on cardiometabolic risk profile in people with coronary artery disease with or without Type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.2021Frontiers in Pharmacology
The effects of glucagon-like peptide-1 receptor agonists on glycemic control and anthropometric profiles among diabetic patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials.2021European Journal of Pharmacology
Comparative efficacy of glucagon-like peptide 1 receptor agonists and sodium glucose cotransporter 2 inhibitors for prevention of major adverse cardiovascular events in type 2 diabetes: a network meta-analysis.2021Journal of Cardiovascular Pharmacology
Systematic review of glucagon-like peptide one receptor agonist liraglutide of subjects with heart failure with reduced left ventricular ejection fraction.2021Current Diabetes Reviews
Comparative effectiveness of dulaglutide versus liraglutide in Asian type 2 diabetes patients: a multi-institutional cohort study and meta-analysis.2020Cardiovascular Diabetology
Comparative effectiveness of glucose-lowering drugs for type 2 diabetes: a systematic review and network meta-analysis.2020Annals of Internal Medicine
Liraglutide reduces systolic blood pressure in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials.2020Clinical and Experimental Hypertension
Major cardiovascular events, heart failure, and atrial fibrillation in patients treated with glucagon-like peptide-1 receptor agonists: an updated meta-analysis of randomized controlled trials.2020Nutrition, Metabolism, and Cardiovascular Diseases
Effectiveness of dulaglutide vs liraglutide and exenatide once-weekly. A real-world study and meta-analysis of observational studies.2020Metabolism: Clinical and Experimental
Association of glucose-lowering medications with cardiovascular outcomes: an umbrella review and evidence map.2020The Lancet. Diabetes & Endocrinology
Analysis of the effect of liraglutide on glycemic variability in patients with type 2 diabetes.2020Endocrine Journal
Effect of liraglutide on blood pressure: a meta-analysis of liraglutide randomized controlled trials.2019BMC Endocrine Disorders
Efficacy of DPP-4 inhibitors, GLP-1 analogues, and SGLT2 inhibitors as add-ons to metformin monotherapy in T2DM patients: a model-based meta-analysis.2019British Journal of Clinical Pharmacology
Comparative effectiveness of exenatide once-weekly versus liraglutide in routine clinical practice: a retrospective multicentre study and meta-analysis of observational studies.2019Diabetes, Obesity & Metabolism
Asian subpopulations may exhibit greater cardiovascular benefit from long-acting glucagon-like peptide 1 receptor agonists: a meta-analysis of cardiovascular outcome trials.2019Diabetes & Metabolism Journal
Effects of exenatide long-acting release on cardiovascular events and mortality in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.2019Acta Diabetologica
Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.2019The Lancet. Diabetes & Endocrinology
Orally administered semaglutide versus GLP-1 RAs in patients with type 2 diabetes previously receiving 1-2 oral antidiabetics: systematic review and network meta-analysis.2019Diabetes Therapy
Cardiovascular outcomes of liraglutide in patients with type 2 diabetes: a systematic review and meta-analysis.2019Medicine
Glucagon-like peptide-1 receptor agonists for antipsychotic-associated cardio-metabolic risk factors: a systematic review and individual participant data meta-analysis.2019Diabetes, Obesity & Metabolism

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