Drug updated on 3/28/2024
| Dosage Form | Suspension (oral; 5 g, 10 g) |
| Drug Class | Potassium binders |
| Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for the treatment of hyperkalemia in adults.
Summary
- Sodium zirconium cyclosilicate (Lokelma) is indicated for the treatment of hyperkalemia in adults.
- Based on 7 systematic reviews/meta-analyses, Lokelma has been found to effectively reduce serum potassium levels and maintain long-term normokalemia in patients with hyperkalemia, including those with chronic kidney disease or heart failure who are at high risk of developing this condition.
- In comparison to other potassium binders such as patiromer and sodium polystyrene sulfonate, Lokelma was associated with a higher rate of achieving normokalemia according to surface under the cumulative ranking area analysis.
- The use of Lokelma also allowed for optimization of renin-angiotensin-aldosterone system inhibitors therapy in heart failure patients by reducing hyperkalemic events and maintaining safe potassium levels.
- However, it should be noted that while effective in managing hyperkalemia, usage of Lokelma may increase the risk of hypokalaemia and edema compared to placebo groups based on pooled data from multiple studies.
- Despite these potential adverse effects, overall safety profile from available data suggests that sodium zirconium cyclosilicate (Lokelma) can be considered a promising long-term treatment option for managing chronic hyperkalaemia among adult patients especially when used alongside renin-angiotensin aldosterone system inhibitor therapies.
Product Monograph / Prescribing Information
| Document Title | Year | Source |
|---|---|---|
| Lokelma (sodium zirconium cyclosilicate) Prescribing Information. | 2022 | AstraZeneca Pharmaceuticals LP, Wilmington, DE |
Systematic Reviews / Meta-Analyses
Clinical Practice Guidelines
| Document Title | Year | Source |
|---|---|---|
| Clinical practice guidelines: treatment of acute hyperkalaemia in adults. | 2020 | The Renal Association |