Drug updated on 3/28/2024
| Dosage Form | Vaginal ring (intravaginal; 103 mg segesterone acetate and 17.4 mg ethinyl estradiol) |
| Drug Class | Combination hormonal contraceptives |
| Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for use by females of reproductive potential to prevent pregnancy.
Summary
- Segesterone acetate and ethinyl estradiol vaginal system (Annovera) is indicated for use by females of reproductive potential to prevent pregnancy.
- Two systematic reviews/meta-analyses were reviewed, providing insights into the acceptability, satisfaction, efficacy, and safety of Annovera in its intended user population.
- The first review found that ease of insertion/removal/reinsertion was high across all settings and improved with time; however ring-related events could lead to discontinuation while general satisfaction ranged between 80-90% among NuvaRing users which tended to mirror continuation rates.
- Sexual satisfaction was less commonly reported in this study with mixed results indicating a need for further research on actual experiences of women using contraceptive vaginal rings (CVRs), relationship aspects, male partner opinions, and contextual norms affecting CVR use.
- The second review highlighted that segesterone acetate/ethinyl estradiol contraceptive vaginal ring represents the first long-lasting user-controlled hormonal contraceptive device showing similar efficacy and safety as other combined hormonal contraceptives but unscheduled removals increase risk of failure.
- This document also emphasized favorable bleeding patterns associated with low discontinuation over an entire year suggesting potential non-contraceptive benefits such as reduced menstrual bleeding but called for more studies evaluating continuous usage beyond 21 days.
Product Monograph / Prescribing Information
| Document Title | Year | Source |
|---|---|---|
| Annovera (segesterone acetate and ethinyl estradiol vaginal system) Prescribing Information. | 2022 | TherapeuticsMD, Inc., Boca Raton, FL |
Systematic Reviews / Meta-Analyses
| Document Title | Year | Source |
|---|---|---|
| Acceptability and Satisfaction of Contraceptive Vaginal Rings in Clinical Studies: A Systematic Review and Narrative Synthesis. | 2021 | Frontiers in Global Women’s Health |
| A technology evaluation of Annovera: a segesterone acetate and ethinyl estradiol vaginal ring used to prevent pregnancy for up to one year. | 2020 | Expert Opinion on Drug Delivery |