Drug updated on 4/15/2024
| Dosage Form | Solution (topical; 0.015 mg/mL) |
| Drug Class | Prostaglandin analogs |
| Ongoing and Completed Studies | ClinicalTrials.gov |
Indication
- Indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Summary
- Tafluprost ophthalmic solution (Zioptan) is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
- Two studies provided a comparative analysis of Zioptan's safety and effectiveness against other drugs used for the same condition.
- One study demonstrated that latanoprostene bunod was numerically superior to tafluprost in lowering intraocular pressure, though the difference was not statistically significant. This indicates that while there may be some advantages to using latanoprostene bunod over tafluprost, these are not conclusively better based on this analysis.
- The second study assessed the impact of combining topical nonsteroidal anti-inflammatory drugs with prostaglandin analogues like tafluprost. It showed enhanced intraocular pressure reduction when combination therapy is used; however, specific details related to tafluprost were not provided.
- Neither study provided detailed information about safety evaluations or subgroup considerations specifically related to Zioptan compared with other drugs beyond measures of effectiveness.
- Further research would be necessary due to the lack of available data regarding factors such as age, severity of condition, or presence of comorbidities.
Product Monograph / Prescribing Information
| Document Title | Year | Source |
|---|---|---|
| Zioptan (tafluprost) Prescribing Information. | 2022 | Théa Pharma Inc., Lexington, MA |
Systematic Reviews / Meta-Analyses
Clinical Practice Guidelines
| Document Title | Year | Source |
|---|---|---|
| European Glaucoma Society terminology and guidelines for glaucoma, 4th edition - Chapter 3: Treatment principles and options supported by the egs foundation. | 2023 | British Journal of Ophthalmology |
| Effect of topical prostaglandin analogue therapy on central corneal thickness: A systematic review. | 2022 | Journal of Clinical Medicine |
| Primary open-angle glaucoma preferred practice pattern. | 2020 | American Academy of Ophthalmology |
| Clinical practice guide for the diagnosis and management of open angle glaucoma. | 2020 | Optometry Australia |